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首页> 外文OA文献 >Induction of a protective capsular polysaccharide antibody response to a multiepitope DNA vaccine encoding a peptide mimic of meningococcal serogroup C capsular polysaccharide
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Induction of a protective capsular polysaccharide antibody response to a multiepitope DNA vaccine encoding a peptide mimic of meningococcal serogroup C capsular polysaccharide

机译：对编码表型脑膜炎球菌血清C群荚膜多糖的肽的多表位DNA疫苗的保护性荚膜多糖抗体的诱导

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Systemic infection by encapsulated organisms, such as Neisseria meningitidis, is a major cause of morbidity and mortality worldwide, especially in individuals less than 2 years of age. Antibodies directed at the capsular polysaccharide are shown to be protective against disease by inducing complement-dependent bactericidal activity. The current polysaccharide vaccine has been shown to be poorly immunogenic in high-risk groups and this is probably related to its T-independent properties. An alternative approach to eliciting a T-dependent serum immunoglobulin G (IgG) antibody response to encapsulated pathogens is DNA vaccination. We assessed the immunogenicity of a multiepitope DNA vaccine encoding a T-cell helper epitope and a peptide mimic of N. meningitidis serogroup C. The DNA construct induced a significant anti-polysaccharide antibody response that was bactericidal. Mice immunized with the DNA construct were subsequently protected against challenge with a lethal dose of N. meningitidis serogroup C.
机译：包膜生物体（例如脑膜炎奈瑟氏球菌）的全身感染是全世界发病率和死亡率的主要原因，尤其是在2岁以下的人群中。通过诱导补体依赖性杀菌活性，针对荚膜多糖的抗体显示出对疾病的保护作用。目前的多糖疫苗已显示在高风险人群中免疫原性较差，这可能与其T非依赖性有关。引发对封装的病原体的T依赖性血清免疫球蛋白G（IgG）抗体应答的另一种方法是DNA疫苗接种。我们评估了编码T细胞辅助抗原决定簇和脑膜炎奈瑟氏球菌血清群C的肽模拟物的多表位DNA疫苗的免疫原性。该DNA构建体诱导了显着的杀菌性抗多糖抗体反应。随后用致死剂量的脑膜炎双球菌血清群C保护用DNA构建体免疫的小鼠免受攻击。

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